AY035
Recombinant BCG overexpressing phoP-phoR
Read MoreBCG w/MK-2206
Parental BCG efficacy is mainly hampered by its low induction of apoptosis along with high secretion of the immunosuppressive cytokine IL-10. We found that the host transcription factor FOXO3 mediates both, BCG-induced apoptosis and inhibition of IL-10 secretion. The novel vaccination procedure consists of induction of FOXO3 activity, during BCG vaccination, using an anti-cancer drug,…
Read MoreBCG::ESX-1Mmar
BCG::ESX-1Mmar is a recombinant BCG strain into which the extended region of the ESX-1-encoding genomic region of Mycobacterium marinum was integrated.
Read MoreVPM1002
VPM1002 is a recombinant, urease C-deficient, listeriolysin expressing BCG vaccine strain and was generated in order to induce a broader immune response against mycobacterial antigens.
Read MoreH56:IC31*
H56:IC31 is an adjuvanted subunit vaccine that combines three M. tuberculosis antigens (Ag85B, ESAT-6 and Rv2660c) with the IC31® adjuvant, from Valneva Austria GmBH.
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